KLS (Kinase Landscape Scanning) Platform
Strategic Kinome Mapping: Zero-Blind-Spot Profiling for TPD Sucess
Kinome Tree Mapping
600+ Kinase Target Identification
Mapping approximately 600 kinases in the human body. Our Kinome Tree Map identifies the correlations and landscape of all targets at a glance, providing the foundation for comprehensive TPD success.
In-house SIL Peptide Synthesis
600+ 13C-Labeled Standards
Proprietary in-house platform synthesizing 600+ SIL peptides. C-terminal Lys or Arg are precisely labeled with 13C to ensure stable mass shifts and absolute quantification accuracy.
TPD Sample & Spiking
PROTAC Treatment & Preparation
13C-SIL peptides are spiked into PROTAC-treated cell samples. This standardized preparation enables ultra-precise measurement of quantitative kinase changes across multiple dose levels.
PROTAC Sample
13C-SIL Standards
LC-DIA-MS/MS Analysis
High-Throughput Quantification
Advanced LC-DIA-MS/MS analysis identifies mass shifts between endogenous (Light) and SIL (Heavy) peptides. > 10 sampling points ensure perfect co-elution and robust ratio-based quantification.
Retention Time
Actionable Intelligence
Heatmap & TPD Success Insight
Converting raw data into strategic insights. Our interactive Heatmaps predict off-target toxicity and elucidate the Mechanism of Action (MoA) to guide optimal drug development.
Ready to accelerate your discovery?
Our KLS™ platform is specifically designed to overcome the hurdles of TPD drug discovery with world-class precision.